HORDB

ID: hor001849
Uniprot ID: Q69GG1
Protein name: Pea-FMRFa-5
Gene name: NA
Organism: Periplaneta americana (American cockroach) (Blatta americana)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: GGKNDNFIRF
Length: 10(121-130)
Propeptide: MGVGIIIAMHALFFFMYHIASSDVLDGTNTIDNVAALDISEDEDDCEPESSITSLPLKRAEEQNQPPPVRRRCSNRNFVRLGRGHDFDQDDVNSSGEKDESLVRIGRGGRSNDNFIRFGRGGKNDNFIRFGRGGKQDNFIRFGRDRSDNFIRFGRGKTDNFIRFGRGRSDNFIRFGRGKSDNFIRFGRARPDNFIRFGRGKQDFIRFGRGNSNFVRFGRDDSSNVETFDTEEEATTDSTLRVGRGGKSGSNFIRF
Signal peptide: MGVGIIIAMHALFFFMYHIASS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Excitatory effects of antenna鈥揾eart;reduce the spike frequency of dorsal鈥恥npaired median neurons and reduce the intracellular calcium concentration
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001849_AF2.pdb

hor001849_ESM.pdb

Mass:	132800	Formula:	C52H78N16O15
Absent amino acids:	ACEHLMPQSTVWY	Common amino acids:	FGN
pI:	9.69	Basic residues:	2
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-96	Boman Index:	-2971
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	39
Instability Index:	-218	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 15355317
Title: Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana